A new booming product, the CBD is increasingly recognized for its natural benefits as we discuss in this article. Thus, it is not uncommon to consume it in addition to conventional drug treatment in the context of certain diseases or chronic pathologies.
But are there dangers and pharmacological interactions to be avoided?
The risks of interactions between taking CBD and certain drugs
The action of CBD on the liver
If you suffer from a pathology and wish use cannabidiol in addition of your treatment, be vigilant. There may be Drugs interactions.
To fully understand the reason, we must take an interest in liver. When we ingest substances, it secretes enzymes. They are intended to metabolize and transform molecules into smaller components and then distribute them throughout the body through the bloodstream.
In the case of a cannabidiol consumption in parallel with drugs, the risk of undergoing an interaction is caused by the inhibitory action of CBD on cytochrome enzymes (CytP450).
It has been shown that it can act on the absorption of ingested drugs. Indeed, the liver will tend to concentrate its efforts on CBD and therefore will not metabolize the drugs administered.
Thus, the latter may not be degraded correctly. Cannabidiol will therefore slow down the proper function of the liver and increase the potential risks of side effects.
What drugs can CBD interact with?
Research has pointed to the potential dangers of interactions in the epilepsy treatment. Combined with clobazam and valproic acid, CBD can lead to an excessive concentration of these molecules in the liver and therefore a risk of overdose and liver toxicity.
In addition, according to an American study published in the journal “Medical Cannabis and Cannabinoids”, it appears that CBD products could interfere with the action of 57 drugs. Among them, we find antidepressants (amitriptyline, clomipramine, lofepramine), analgesics (fentanyl), oral contraceptives based on ethinyl estradiol, sedatives (propofol), anti-coagulants (warfarin and acenocoumarol) and drugs to treat thyroid (levothyroxine).
Consequently, the effectiveness of the drug ingested may be reduced, risks of drowsiness or cardiovascular accidents may also be generated.
To avoid any danger, we recommend you to do not self-medicate CBDespecially when you are taking medication.
It’s important to always seek the advice of your doctor.